4-Chloro-3-(Trifluoromethyl)phenyl Isocyanate CAS 327-78-6 Purity ≥99.0% Sorafenib Tosylate Intermediate Factory

Short Description:

4-Chloro-3-(Trifluoromethyl)phenyl Isocyanate 

CAS: 327-78-6

Appearance: White Crystalline

Purity: ≥99.0% (HPLC) 

Intermediate of Sorafenib Tosylate (CAS: 475207-59-1) in the treatment of RCC & HCC 

Contact: Dr. Alvin Huang 

Mobile/Wechat/WhatsApp: +86-15026746401 

E-Mail: alvin@ruifuchem.com  


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Sorafenib Tosylate Intermediates:

327-78-6 - Description:

Shanghai Ruifu Chemical Co., Ltd. is the leading manufacturer of 4-Chloro-3-(Trifluoromethyl)phenyl Isocyanate (CAS: 327-78-6) with high quality, intermediate of Sorafenib Tosylate (CAS: 475207-59-1). Ruifu Chemical can provide worldwide delivery, competitive price, excellent service, small and bulk quantities available. Purchase Sorafenib Tosylate Intermediates, Please contact: alvin@ruifuchem.com 

327-78-6 - Chemical Properties:

Name 4-Chloro-3-(Trifluoromethyl)phenyl Isocyanate
Synonyms Isocyanic Acid 4-Chloro-3-(Trifluoromethyl)phenyl Ester; 4-Chloro-α,α,α-Trifluoro-m-Tolyl Isocyanate
CAS Number 327-78-6
Stock Status In Stock, Production Scale Up to Tons
Molecular Formula C8H3ClF3NO
Molecular Weight 221.56
Melting Point 37.0~42.0℃ (lit.)
Boiling Point 86.0~90.0℃/14 mmHg (lit.)
Flash Point 99℃(210°F)
Density 1.4720 
Sensitive Moisture Sensitive, Heat Sensitive
Storage Condition Store Under Inert Gas (Nitrogen or Argon) at 2~8℃
Shipping Conditions Ambient
COA & MSDS Available
Place of Origin  Shanghai, China
Brand Ruifu Chemical

327-78-6 - Specifications:

Item Specifications Results
Appearance   White Crystalline White Crystalline
Purity / Analysis Method ≥99.0% (HPLC) 99.74%
Identification (1) IR / (2) HPLC Conforms
Moisture (K.F) ≤0.50% 0.06%
Residue on Ignition ≤0.50% 0.11%
Heavy Metals ≤10ppm <10ppm
Ordinary Impurities
Impurity A ≤0.15% 0.00%
Impurity B ≤1.00% 0.26%
Impurity C ≤1.00% 0.00%
Other Single Impurity ≤0.50% 0.26%
Total Impurities ≤1.00% 0.26%
Residual Solvent Toluene  ≤0.089% 0.00%
Conclusion The product has been tested and complies with the given specifications
Application  Intermediate of Sorafenib Tosylate (CAS: 475207-59-1)

Package/Storage/Shipping:

Package: Fluorinated Bottle, Aluminium foil bag, 25kg/Cardboard Drum, or according to customer's requirement.
Storage Condition: Keep the container tightly closed and store in a cool, dry and well-ventilated warehouse away from incompatible substances. Store keep far away from sunlight, sealed at a temperature below 25℃ and forbidden to contact alcohols organic solvent and water.
Shipping: Deliver to worldwide by air, by FedEx / DHL Express. Provide fast and reliable delivery. 

Advantages:

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327-78-6 - Risk and Safety:

Hazard Symbols Xn - Harmful
Risk Codes R20/21/22 - Harmful by inhalation, in contact with skin and if swallowed.
R36/37 - Irritating to eyes and respiratory system.
R36/37/38 - Irritating to eyes, respiratory system and skin.
R42 - May cause sensitization by inhalation
R20/22 - Harmful by inhalation and if swallowed.
Safety Description S7 - Keep container tightly closed.
S26 - In case of contact with eyes, rinse immediately with plenty of water and seek medical advice.
S27 - Take off immediately all contaminated clothing.
S37/39 - Wear suitable gloves and eye/face protection
S36/37/39 - Wear suitable protective clothing, gloves and eye/face protection.
S45 - In case of accident or if you feel unwell, seek medical advice immediately (show the label whenever possible.)
S23 - Do not breathe vapour.
UN IDs UN 2206 6.1/PG 3
WGK Germany 3
HS Code 2929109000
Hazard Note Harmful / Moisture Sensitive
Hazard Class 6.1
Packing Group III

327-78-6 - Application:

Sorafenib Tosylate (CAS: 475207-59-1) is a new type of multi-target antitumor drug, was developed by the German Bayer Pharmaceuticals, and displayed expansive antitumor activity in preclinical animal tests. Sorafenib is available in 200-mg tablets for oral administrationand is used in the treatment of RCC and HCC. Sorafenib Tosylate (CAS: 475207-59-1) can simultaneously affect tumor cells and tumor blood vessels. It has a double antitumor effect: it can block the cell signal transduction pathways mediated by RAF/MEK/ERK to directly inhibit tumor cell growth, while also inhibiting VEGF and platelet derived growth factors (PDGF) receptors to prevent the formation of new tumor blood vessels, thus indirectly inhibiting tumor cell growth. 

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